Vol. 43 (3): 383-384, May – June, 2017

doi: 10.1590/S1677-5538.2017.03.02


Wanderley Marques Bernardo
Faculdade de Medicina da Universidade de São Paulo (FMUSP),
Projeto Diretrizes – Associação Médica Brasileira (AMB),
São Paulo, SP, Brasil


Independent of who made the first Review in health literature, it is possible to state that the development of the fundamental concepts on Systematic Review and Meta-analysis is attributable to the Cochrane initiative, that signalized the need to gather scientific evidence based on the opinion of medical specialists (1). It is necessary to periodically organize a synthesis, by specialty, of all relevant randomized clinical trials, which stimulated, in 1993, the creation of collaboration, which has been at the forefront of the methodology and in the rigorous systematic review.

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