Vol. 42 (3): 422-430, May – June, 2016

doi: 10.1590/S1677-5538.IBJU.2015.0095


Metabolic syndrome and prostatic disease: potentially role of polyphenols in preventive strategies. A review

Tommaso Castelli 1, Giorgio Ivan Russo 1, Giulio Reale 1, Salvatore Privitera 1, Mario Chisari 1, Eugenia Fragalà 1, Vincenzo Favilla 1, Sebastiano Cimino 1, Giuseppe Morgia 1

1 Dipartimento di Urologia, Facoltà di Medicina Policlinico, Università di Catania, Italia


Benign prostatic hyperplasia and prostate cancer are two common urological diseases of the elderly. Scientific community has always looked for a link that could explain the correlation between the two diseases and the role of chronic inflammation in the pathogenesis of BPH and PCa. As shown by the reports of the two diseases relationship with oxidative stress and metabolic syndrome, the use of compounds with antioxidant action could therefore affect both the symptoms and their onset. Polyphenols appear to act not only against oxidative stress but also at different levels. The aim of this review is to evaluate the role of the most important polyphenols on these two urological diseases. As antioxidants these compounds seems to have a direct action on the cell cycle and hormone function, important for both prostate cancer and BPH. Despite a large number of articles about the relationship of the polyphenols with prostate cancer, very little evidence exists for BPH. Additional clinical trials or meta-analysis are necessary on this topic.

Keywords: Oxidative Stress; Prostatic Hyperplasia; Prostatic Neoplasms; Polyphenols

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